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Engineered human fusion protein inhibits HIV-1 replication
8. 9 2009 (06:00)
Fusion protein AoT5Cyp blocks HIV-1 infection in owl monkeys. The human genome encodes the equivalent of the 2 components of AoT5Cyp (TRIM5 and cyclophilin A), but humans unfortunately do not make the fusion protein. Researchers have now fused human cyclophilin A and TRIM5 and this protein inhibited HIV-1 replication in human macrophages, T cells and mice engrafted with human CD4+ T cells containing the protein. This protein may be an anti-HIV-1 gene therapy candidate.
