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'ROCK' off: Study establishes molecular link between genetic defect and heart malformation
6. 2 2012 (06:00)
UNC researchers have discovered how the genetic defect underlying one of the most common congenital heart diseases keeps the critical organ from developing properly. According to the new research, mutations in a gene called SHP-2 distort the shape of cardiac muscle cells so they are unable to form a fully functioning heart. The study also shows that treatment with a drug that regulates cell shape rescues the cardiac defect.
