Unexpected findings in patients with limbic encephalitis will change disease diagnosis and classification

New findings indicate that the target of autoantibodies that are associated with limbic encephalitis is LGI1 - a protein involved in fine-tuning of neuronal synapses. The results suggest that testing for these antibodies to LGI1 is diagnostic for limbic encephalitis, and mean that the current classification of the disease should be changed, concludes an Article published Online First and in the August edition of The Lancet Neurology.